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. 2018 Jul 18;51(2):576–592. doi: 10.4143/crt.2018.100

Fig. 1.

Fig. 1.

Upregulation of paired-like homeodomain transcription factor 2 (PITX2) expression in letrozole-resistant breast cancer (BCa) tissues and cells. (A) PITX2 expression in normal breast tissues, primary BCa tissues and recurrent BCa tissues was determined using quantitative real-time polymerase chain reaction (RT-qPCR). Fold change was determined for each sample relative to the internal control gene 18S. Each value is a mean±standard error of mean from three experiments. (B) Representative fields of normal breast tissues, primary BCa tissues and recurrent BCa tissues immunohistochemically stained with anti-PITX2 antibody as indicated. Scale bar=20 μm. (C) Characterization of PITX2 expression in different BCa cells using RT-qPCR. (D) Western blotting analysis of PITX2 expression in different BCa cells. Actin served as the loading control.