Fig. 5.

Intrinsic taxane resistance (ITR)‒trained model performances on internal (ITR) and external validation (acquired taxane resistance [ATR]) cohorts. Receiver operating characteristic (ROC) and precision-recall curve are used to show ability to predict. (A) Model performances on internal validation of ITR cohorts (CCLE-PTX, CGP-DTX, and CGP-PTX). (B) Model performances on external ATR cohorts. AUC, area under the curve; CCLE, Cancer Cell Line Encyclopedia; PTX, paclitaxel; CGP, Cancer Genome Project; DTX, docetaxel.