Table 2.
Baseline characteristics of patients with an exon 20 insertion mutation
| Early-stage (n=29) | Refractory NSCLC (n=27) | Total (n=56) | |
|---|---|---|---|
| Age at diagnosis (yr) | 60 (36-78) | 60 (43-75) | 60 (36-78) |
| Sex | |||
| Female | 14 (48.2) | 11 (40.7) | 25 (44.6) |
| Male | 15 (51.8) | 16 (59.3) | 33 (55.4) |
| Histology | |||
| ADC | 29 (100) | 26 (96.3) | 55 (98.2) |
| SqCC | 0 | 1 (3.7) | 1 (1.8) |
| ECOG | |||
| 0 | 8 (27.6) | 1 (3.8) | 9 (16.1) |
| 1 | 21 (72.4) | 19 (70.3) | 40 (71.4) |
| 2 | 0 | 7 (25.9) | 7 (12.5) |
| Smoking history | |||
| Never | 19 (65.5) | 21 (77.8) | 40 (71.4) |
| Current | 6 (20.7) | 3 (11.1) | 9 (16) |
| Ex | 4 (13.8) | 3 (11.1) | 7 (12.6) |
| Metastasis | |||
| CNS | - | 11 | - |
| Bone | - | 9 | - |
| Liver | - | 5 | - |
| Lung | - | 9 | - |
| Exon 20 mutation | |||
| Insertion only | 25 (8-6.2) | 23 (85.2) | - |
| Double mutation | |||
| Insertion+S768I | - | 1 (3.7) | - |
| Insertion+G719S | - | 1 (3.7) | - |
| Insertion+Deletion 19 | 4 (13.8) | - | - |
| Insertion+L858R | - | 2 (7.4) | - |
Values are presented as median (range) or number (%). NSCLC, non-small cell lung cancer; ADC, adenocarcinoma; SqCC, squamous cell carcinoma; ECOG, Eastern Cooperative Oncology Group; CNS, central nervous system.