Table 4.
Associations from the genome-wide association stage data for SNPs showing significance in previously reported GWAS studies
| SNP | Chr | Gene | GWAS in previous report |
GWAS stage in this study |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ethnicity | Effect | Cont Afreq | p-value | OR (95% CI) | Maj | Min | Case Afreq | Cont Afreq | p-value | OR (95% CI) | |||
| rs140081212 [11] | 1 | - | European (Icelanders) | A | 0.65 | 7.90E-10 | 0.79 (0.73-0.86) | G | A | 0.09 | 0.12 | 0.0366 | 0.73 (0.55-0.96) |
| rs760077 [11] | 1 | MTX1 | European (Icelanders) | A | 0.65 | 1.10E-08 | 0.79 (0.73-0.85) | T | A | 0.09 | 0.11 | 0.0152 | 0.71 (0.54-0.94) |
| rs6676150 [11] | 1 | - | European (Icelanders) | C | 0.67 | 1.50E-08 | 0.80 (0.74-0.86) | G | C | 0.06 | 0.10 | 0.0018 | 0.61 (0.44-0.83) |
| rs2274223[7] | 10 | PLCE | Asian (Chinese) | G | 0.21 | 8.40E-09 | 1.31 (1.19-1.43) | C | T | 0.26 | 0.26 | 0.4074 | 1.08 (0.90-1.30) |
| rs3765524[7] | 10 | PLCE | Asian (Chinese) | T | 0.21 | 5.32E-09 | 1.31 (1.20-1.44) | C | T | 0.26 | 0.26 | 0.5340 | 1.08 (0.90-1.30) |
| rs9841504[8] | 3 | Asian (Han Chinese) | G | 0.15 | 1.70E-09 | 0.76 (0.69-0.83) | - | - | - | - | - | - | |
| rs13361707 [8] | 5 | Asian (Han Chinese) | C | 0.48 | 7.60E-29 | 1.41 (1.32-1.49) | - | - | - | - | - | - | |
| rs10074991 [10] | 5 | PRKAA1 | Asian (China, Korea) | A | 0.48 | 4.83E-26 | 0.80 (0.77-0.83) | - | - | - | - | - | - |
| rs2294693 [10] | 6 | UNC5CL, TSPO2 | Asian (China, Korea) | C | 0.24 | 7.22E-08 | 1.14 (1.09-1.20) | - | - | - | - | - | - |
| rs4072037 [10] | 1 | MUC1 | Asian (China, Korea) | G | NR | 7.00E-08 | 1.32 (1.19-1.45) | T | C | 0.12 | 0.14 | 0.2070 | 0.82 (0.64-1.05) |
| rs2494938[9] | 6 | LRFN2 | Asian (Han Chinese) | A | 0.26 | 4.91E-09 | 1.18 (1.12-1.25) | - | - | - | - | - | - |
| rs2285947[9] | 7 | DNAH11 | Asian (Han Chinese) | A | 0.27 | 1.36E-06 | 1.14 (1.08-1.21) | G | A | 0.32 | 0.32 | 0.7298 | 0.99 (0.84-1.17) |
SNP, single-nucleotide polymorphism; GWAS, genome-wide association study; Chr, chromosome; ContAfreq, control allele frequency; OR, odds ratio; CI, confidence interval; Maj, major allele; Min, minor allele.