Skip to main content
. 2019 Mar 19;11(3):514. doi: 10.3390/polym11030514

Table 1.

Controlled delivery of nonviral vectors via supramolecular-based CD hydrogels.

Polymers/CDs Vectors Outcomes Approaches Targets References
PF68-PLL/α-CD pDNA-GFP Sustained pDNA delivery for 80 h; transfection efficiency ~14% mouse fibroblast cells 3T3 n.s. [9]
MPEG-PCL-PDMAEMA/α-CD pDNA-luc Sustained release of pDNA up to 6 days; transfection efficiency comparable to freshly prepared PEI polyplexes COS-7 cells n.s. [13]
PEG-α-CD-cross-linked PVDT pDNA-luc Efficient reverse gene transfection of cells cultured on the gel surface COS-7 cells n.s. [39]
MPEG-PCL-PEI/α-CD MPEG-PCL-PEIFA/α-CD pDNA-GFP
pDNA-Nur77
Sustained release of pDNA for 7 days; transfection efficiency of 63% at optimal weight ratio of 1.5; significant inhibition of therapeutic resistant tumor growth with high expression of Bcl-2 proteins
Higher efficiency when combining the chemotherapeutic agent paclitaxel and the targeting ability of FA
HEK293 cells, tumor model (BALB/c nude mice) tumor [15,40]
MPEG-PLLD-Arg/α-CD pMMP-9 Controlled release for 6 days; transfection efficiency up to 72%; sustained tumor growth inhibition after 21 days with good biocompatibility HNE-1 cells, nude mice bearing HNE-1 tumors tumor [37]

Abbreviations: CD: cyclodextrin; Pluronic® F68; PLL: poly(l-lysine); α-CD: alpha-CD; MPEG-PCL-PDMAEM:. methoxy-poly(ethylene glycol)-b-poly(ε-caprolactone)-b-poly[2-(dimethylamino)ethyl methacrylate]; PEG: poly-ethylene glycol; β-CD: beta-CD; PVDT: poly-2-vinyl-4,6-diamino-1,3,5-triazine; PEI: poly(ethylene imine); PLLD-Arginine-functionalized PLL dendron; pDNA: plasmid DNA; GFP: green fluorescent protein; luc: luciferase; Nur 77: Bcl-2 (B-cell lymphoma 2) conversion Nur77 gene; FA: folic acid; MMP-9: matrix metalloproteinase 9; HNE-1: human nasopharyngeal carcinoma HNE-1 cells; n.s.: not specified.