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. 2019 Apr 12;9:265. doi: 10.3389/fonc.2019.00265

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Copyright © 2019 Weinberger, Bednarikova, Hausnerova, Ovesna, Vinklerova, Minar, Felsinger, Jandakova, Cihalova and Zikan.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Microphotographs showing representative examples of immunohistochemical expression of estrogen receptors (ER), progesterone receptor (PR), L1CAM and p53 in tissue specimens of endometrial carcinomas. Magnification 100x. (A) Complete negativity of ER expression in serous carcinoma with 0% cells positive; (B) Complete negativity of PR expression in serous carcinoma with 0% cells positive; (C) Strong diffuse membranous positivity of L1CAM expression in serous carcinoma with 100% cells positive; (D) p53 nuclear overexpression (mutant pattern) in serous carcinoma; (E) Nuclear positivity of ER expression in grade 1 endometrioid carcinoma with almost 100% cells positive; (F) nuclear positivity of PR expression in grade 1 endometrioid carcinoma with almost 100% cells positive; (G) complete negativity of L1CAM expression in grade 1 endometrioid carcinoma with 0% cells positive; (H) p53 wildtype immunohistochemical pattern in grade 1 endometrioid carcinoma.