Table 3.
Biopsy diagnosis | Dallas criteria | WHF criteria histology* | WHF criteria viral etiology |
---|---|---|---|
1st EMB: Active myocarditis | Infiltrate (>5 per hpf or nests), myocytolysis, edema (only H&E staining) |
>50/mm2 = fulminant m. >14/mm2 = active m. |
(Quantitative) PCR on viruses If positive: viral m. or DCMi; If negative: autoreactive m. |
Borderline myocarditis | Infiltrate (>5 per hpf or nests), (only H&E staining) | Not applicable | Not applicable |
No myocarditis | No infiltrate | < 14/mm2 | If negative: DCM If positive: viral DCM |
2nd EMB: Ongoing myocarditis | Infiltrate (>5 per hpf or nests), myocytolysis, edema (only H&E staining) |
>14/mm2 | (Quantitative) PCR on viruses, If positive: viral m. or DCMi; If negative: autoreactive m. |
Healed/resolved myocarditis | No infiltrate, but focal fibrosis | < 14/mm2 | If negative: DCM If positive: viral DCM |