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. 2019 Apr 12;6:48. doi: 10.3389/fcvm.2019.00048

Table 3.

Comparison of qualitative Dallas (14) and quantitative World Heart Federation (WHF) criteria (15, 16).

Biopsy diagnosis Dallas criteria WHF criteria histology* WHF criteria viral etiology
1st EMB: Active myocarditis Infiltrate (>5 per hpf or nests), myocytolysis,
edema (only H&E staining)		 >50/mm2 = fulminant m.
>14/mm2 = active m.		 (Quantitative) PCR on viruses
If positive: viral m. or DCMi; If negative: autoreactive m.
Borderline myocarditis Infiltrate (>5 per hpf or nests), (only H&E staining) Not applicable Not applicable
No myocarditis No infiltrate < 14/mm2 If negative: DCM
If positive: viral DCM
2nd EMB: Ongoing myocarditis Infiltrate (>5 per hpf or nests), myocytolysis, edema
(only H&E staining)		 >14/mm2 (Quantitative) PCR on viruses,
If positive: viral m. or DCMi; If negative: autoreactive m.
Healed/resolved myocarditis No infiltrate, but focal fibrosis < 14/mm2 If negative: DCM
If positive: viral DCM