Table 1.

Modification of gastric bacterial microbiome composition and abundance during Helicobacter-associated disease.

Analytical Method	Pathophysiological Context	Modification in Bacterial Abundance	References
Culture method	Healthy patient	Veillonella sp., Lactobacillus sp., Clostridium sp. Propionibacterium, Streptococcae and Staphylococcae	Zilberstein et al. 2007 [19]
16S rRNA sequencing		Proteobacteria, Firumicutes, Bacteroidetes, Actinobacteria and Fusobacteria (Streptococcae and Prevotella)	Li et al. 2009 [20] Bik et al. 2006 [21]
Molecular biology	Mice models	Increase in Clostridia, Bacteroides/Prevotella spp., Eubacterium spp., Ruminococcus spp., Streptococci and Escherichia coli Decrease in Lactobacilli	Aebischer et al. 2006 [24]
16S rRNA microarray	Chronically infected patient	Decrease of Actinobacteriae, Bacteroidetes and Firmicutes Increase of Spirochetes, acidobacteriae and Proteobacteriae	Moldonado-Contreras et al. 2011 [10]
Culture method	Under-therapies patients	Decrease of Bifidobacteria or Clostridia. Increase of Enterococci, Enterobacteria and Peptostreptococci	Adamson et al. 2000 [25]
16S rRNA sequencing	Under-therapies patients	Increase of Bacteroidetes Decrease Actinobacteria, Bifidobacteriales No modification of Lactobacillus	Gotoda et al. 2018 [26]
16S rRNA sequencing	Gastritis	Decrease of Proteobacteria (phyla) and of Prevotella (level) Increase of Firmicutes (phyla) and of Streptococcus (genera)	Li et al. 2009 [20]
16S rRNA microarray	Invasive gastric cancer	Decrease in Porphyromonas, Neisseria and Streptococcus sinensis Increase in Lactobacillus L. coleohomonis and Lachnospiraceae	Aviles-Jimenez et al. 2014 [27]