Table 2.
Clinical laboratory parameters and inflammatory cytokines in symptomatic PEL compared with KSHV-MCD and HIV-DLBCL
| Parameter | PEL | KSHV-MCD | P | HIV-DLBCL | P |
|---|---|---|---|---|---|
| Clinical laboratory parameter, median (IQR) | |||||
| CD4 cells/µL | 127 (53, 389) | 266 (186, 670) | .041 | 52 (24, 193) | .021 |
| Hemoglobin, g/dL | 9.2 (7.9, 11.4) | 9.9 (8.8, 11.7) | .42 | 10.7 (9.4, 12.2) | .12 |
| Platelets ×1000/µL | 106 (30, 247) | 112 (49, 262) | .58 | 229 (176, 310) | .0045 |
| Albumin, mg/dL | 2.1 (1.6, 2.9) | 2.7 (2.0, 3.0) | .11 | 3.4 (2.6, 3.8) | .0027 |
| Sodium, mEq/L | 133 (132, 140) | 134 (130, 138) | .71 | 134 (137, 140) | .28 |
| Inflammatory cytokines, median (IQR) | |||||
| IFN-γ, pg/mL | 11.7 (2.7, 33) | 3.8 (2.2, 11) | .16 | 14.2 (5.2, 35) | .71 |
| IL-10, pg/mL | 187 (111, 10K) | 310 (47, 1824) | .47 | 11.7 (2.0, 53) | <.0001 |
| IL-12p70, pg/mL | 7 (1.8, 17.7) | 4.6 (2.5, 12.3) | .73 | 1.4 (0.4, 2.9) | .0093 |
| IL-1β, pg/mL | 1.6 (0.6, 3.1) | 1.1 (0.6, 1.9) | .50 | 0.5 (0.3, 1.2) | .019 |
| IL-6, pg/mL | 15.2 (7.4, 42) | 18 (7.6, 52) | .89 | 5.0 (2.9, 16) | .047 |
| IL-8, pg/mL | 38 (25, 90) | 39 (14, 111) | .77 | 49 (28, 137) | .57 |
| TNF-α, pg/mL | 25 (12, 44) | 27 (18, 44) | .75 | 25 (11, 35) | .90 |
| KSHV VL, copies/106 PBMC | 28.6K (500, 116K) | 20.7K (2250, 154K) | .89 | 0 (0, 0) | <.0001 |
| EBV VL, copies/106 PBMC | 1580 (35, 4333) | 488 (1, 1692) | .09 | 613 (1, 2769) | .31 |
P values are comparisons between PEL and either KSHV-MCD or HIV-DLBCL according to Wilcoxon rank sum test. P < .005 is considered statistically significant; P < .05 is considered a strong trend.
IQR, interquartile range; VL, viral load.