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. 2019 Mar 18;6(1):41. doi: 10.3390/medicines6010041

Table 1.

Genetic variants associated with NAFLD.

Gene Effect on NAFLD/NASH
Palatine like phospholipase domain containing 3 (PNPLA-3) [15,16,17] Increased risk of hepatic steatosis, incidence of NASH and severity of fibrosis
Farnesyl diphosphate farnesyl transferase I (FDFT1) [19] Increased severity of NAFLD activity score
Collagen type XIII alpha 1 (COL13A1) [19] Increased severity of fibrosis
Neurocan (NCAN) [19] Increased risk hepatic steatosis
Glucokinase regulatory protein (GCKR) [19] Increased risk hepatic steatosis
Transmembrane 5 superfamily member 2 (TM6SF2) [21] Increased risk for hepatic fibrosis