Table 5.
Influenza virus detection in ferret respiratory tract tissues.
| Virus | Inoculation Dose a | Mean Titer (log 10 PFU/mL or g) ± SD b | Data Source | ||
|---|---|---|---|---|---|
| Nasal Turbinates | Trachea | Lung | |||
| 1918 c | 6.0 | 5.3 ± 0.9 (3/3) | 5.7 ± 0.5 (3/3) | 5.4 ± 0.7 (3/3) | [95] |
| MN/45 | 6.0 | 5.3 ± 0.2 (3/3) | 4.5 ± 1.0 (3/3) | 3.8 ± 2.0 (3/3) | [53] |
| TX/14 | 6.0 | 4.7 ± 1.0 (3/3) | 4.1 ± 1.9 (3/3) | 6.0 ± 1.0 (3/3) | [98] |
| OH/02 | 6.0 | 5.0 ± 0.7 (3/3) | 4.3 ± 0.4 (3/3) | 4.8 ± 1.0 (3/3) | [98] |
| OH/09 | 5.0 | 6.1 ± 0.6 (3/3) | 4.1 ± 0.6 (3/3) | 2.7 ± 0.9 (2/3) | [31] |
| IA/39 | 5.0 | 5.1 ± 0.1 (3/3) | 3.9 ± 0.3 (3/3) | 4.3 ± 0.4 (3/3) | [31] |
| Mex/4482 | 6.0 | 5.8 ± 0.8 (3/3) | 5.0 ± 0.8 (3/3) | 5.3 ± 0.6 (2/3) | [94] |
| CA/04 | 6.0 | 4.6 ± 0.3 (3/3) | 5.0 ± 1.2 (3/3) | 5.8 ± 0.4 (3/3) | [94] |
| CA/07 | 5.0 | 4.9 ± 0.3 (3/3) | 4.9 ± 0.3 (3/3) | 4.4 ± 1.4 (3/3) | [31] |
| TX/15 | 6.0 | 4.6 ± 0.3 (3/3) | 5.7 ± 0.3 (3/3) | 6.0 ± 1.0 (3/3) | [94] |
| Bris/59 | 6.0 | 5.6 ± 0.6 (3/3) | 2.6 ± 0.1 (3/3) | ND (0/3) | [94] |
| WI/71 | 6.0 | 4.9 ± 0.5 (3/3) | 4.6 ± 0.5 (3/3) | 4.1 ± 0.5 (3/3) | [53] |
| MN/19 | 6.0 | 4.2 ± 0.5 (3/3) | 4.1 ± 1.4 (3/3) | 3.7 ± 1.0 (3/3) | [53] |
a Each ferret was intranasally inoculated with 1 mL of the specified dose of virus (log10 PFU) diluted in PBS. b Mean virus titers in tissues collected on day three post inoculation ± SD. Nasal turbinate viral titers are presented as log10 PFU/mL and trachea and lung titers are presented as log10 PFU/g of tissue. Number of ferrets with detectable titers are indicated in parenthesis. c Reconstructed A/South Carolina/1/1918 virus [72]. ND- not detected.