Chang 2007.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: six weeks. Design: parallel. Setting: inpatient, China. |
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Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more.
N = 100.
Age: aripiprazole group: 18~48 years. mean= (29.5 ± 11.7) years; risperidone group: 16~60 years, mean = (29.3 ± 10.6) years. Gender: aripiprazole group: 29 male, 21 female; risperidone group: 28 male, 22 female. History: aripiprazole group: 1 month~10 years, mean = (6.4 ± 1.5) years; risperidone group: 1.5 months~13 years, mean = (6.3 ± 1.8) years. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Dose range: 5‐20 mg/day. Mean dose: not reported. N = 50. 2. Risperidone: Dose range: 1‐4 mg/day. Mean dose:not reported. N = 50. | |
Outcomes | Globlal state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐ 75%, improved: 25%‐50%, no effect: < 25%). Mental state: PANSS total score, PANSS positive subscale score, PANSS negative subscale score,PANSS general pathological subscale score, irritability‐ labelled as "adverse effect". Adverse effects. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No incomplete data. |
Selective reporting (reporting bias) | High risk | Data on TESS total score, blood glucose, liver function, use of benzodiazepines and other medicines were missing. |
Other bias | Low risk | None obvious. |