Ge 2009.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: eight weeks. Design: parallel. Location: inpatient, China. | |
Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more.
N = 80. Age: 18~40 years, aripiprazole group: mean = (22.1 ± 5.9) years; quetiapine group: mean = (24.8 ± 7.2) years. Gender: Not reported. History: aripiprazole group: mean = (1.1 ± 0.7) years; quetiapine group: mean = (1.3 ± 0.7) years. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Initial dose: 5 mg/day. Mean = (25.5 ± 1.8) mg/day. N = 40. 2. Quetiapine: Initial dose: 100mg/day. Mean = (425 ± 27) mg/day. N = 40. | |
Outcomes | Mental state: PANSS total score. PANSS positive subscale score, PANSS negative subscale score, PANSS general psychogenic pathological subscale score. Adverse effects. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Unclear if there were incomplete data. |
Selective reporting (reporting bias) | High risk | Although TESS was used to assess adverse effects, no data on score were available. |
Other bias | Low risk | None obvious. |