Li 2007d.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: 1~2 weeks wash‐out period + eight weeks intervention. Design: parallel. Setting: inpatient, China. |
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Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more.
N = 120.
Age: aripiprazole group: 16~60 years. mean = (28. 4 ± 9. 1) years; risperidone group: 17~56 years, mean = (29. 6 ± 8. 3) years. Gender: aripiprazole group: 28 male, 32 female; risperidone group: 46 male, 14 female. History: aripiprazole group: mean = (2.3 ± 1.8) months; risperidone group: mean = (2.4 ± 1.6) months. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Dose range: 5‐30 mg/day. Mean dose: not reported. N = 60. 2. Risperidone: Dose range: 1‐6 mg/day. Mean dose: not reported. N = 60. | |
Outcomes | Global state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐75%, improved: 25%‐50%, no effect: < 25%). CGI‐SI, CGI‐GI. Mental state: PANSS total score, PANSS positive subscale score, PANSS negative subscale score, PANSS psychopathological subscale score. agitation‐labelled as "adverse effect". Adverse effects. Unable to use ‐ Adverse effects: TESS total score, blood routine, renal function, PRL, use of benzodiazepines and anticholinergic medication (no data). |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No incomplete data. |
Selective reporting (reporting bias) | High risk | Data on TESS total score, blood routine, renal function, PRL, use of benzodiazepines and anticholinergic medication were missing. |
Other bias | Low risk | None obvious. |