Liu 2006a.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: eight weeks. Design: parallel. Setting: inpatient, China. |
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Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more.
N = 90.
Age: aripiprazole group: 18~ 56 years, mean = (28 ± 4.6) years, risperidone group: 18~58 years, mean = (30.1 ± 5) years. Gender: aripiprazole group: 26 male, 19 female; risperidone group: 23 male, 22 female. History: aripiprazole group: 1 month~5 years, mean = (3.6 ± 2.1) years; risperidone group: 1 month~5.2 years, mean = (3.8 ± 2.4) years. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Dose range: 10‐30 mg/day. Mean dose: not reported. N = 45. 2. Risperidone: Dose range: 1‐6 mg/day. Mean dose: not reported. N = 45. | |
Outcomes | Global state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐75%, improved: 25%‐50%, no effect: < 25%). Mental state: PANSS total score. PANSS positive subscale score, PANSS negative subscale score, PANSS general psychogenic pathological subscale score. agitation/excitement labelled as "adverse effect". Adverse effects. Unable to use ‐ Adverse effects: TESS score, blood routine, blood glucose, use of benzodiazepines, benzhexol (no data). |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details.. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No incomplete data. |
Selective reporting (reporting bias) | High risk | Data on TESS score,blood routine, blood glucose, use of benzodiazepines, benzhexol were missing. |
Other bias | Low risk | None obvious. |