Liu 2009.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: eight weeks. Design: parallel. Setting: inpatient and outpatient, China. |
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Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more.
N = 68.
Age: aripiprazole group: mean = (26.1 ± 7.5) years; olanzapine group: mean = (27.4 ± 8.4) years. Gender: aripiprazole group: 18 male, 16 female; olanzapine group: 17 male, 17 female. History: aripiprazole group: mean = (6.9 ± 3.4) years; olanzapine group: mean = (6.5 ± 3.6) years. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Dose range: 10‐30 mg/day. Mean = (19.7 ± 5.3) mg/day. N = 34. 2. Olanzapine: Dose range: 10‐20 mg/day. Mean = (15.4 ± 4.5) mg/day. N = 34. | |
Outcomes | Mental state: PANSS total score, PANSS positive subscale score, PANSS negative subscale score, PANSS psychopathological subscale score. Quality of life: GQOLI‐ 74 total score, GQOLI‐ 74 material life score, GQOLI‐ 74 physical health score, GQOLI‐ 74 mental health score, GQOLI‐ 74 social function score. Adverse effects. |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Unclear if there were incomplete data. |
Selective reporting (reporting bias) | High risk | Data on TESS total score, use of benzodiazepines and benzhexol were missing. |
Other bias | Low risk | None obvious. |