Ma 2009a.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: eight weeks. Design: parallel. Setting: outpatient, China. |
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Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more.
N = 98.
Age: 18~55 years, mean = (32 ± 18.79) years. Gender: 43 male, 55 female. History: not reported. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Dose range: 5‐20 mg/day. Mean dose: not reported. N = 49. 2. Risperidone: Dose range: 1‐5 mg/day. Mean dose: not reported. N = 49. | |
Outcomes | Global state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐75%, improved: 25%‐50%, no effect: < 25%). Mental state: PANSS total score, PANSS positive subscale score, PANSS negative subscale score, PANSS general psychogenic pathological subscale score. Adverse effect. Unable to use ‐ Adverse effects: TESS total score, tremor, dry mouth, dystonia, use of benzhexol, benzodiazepine and propranolol (no data) . |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | There were no incomplete data. |
Selective reporting (reporting bias) | High risk | Data of TESS total score, tremor, dry mouth, dystonia, use of benzhexol, benzodiazepine and propranolol were missing. |
Other bias | Low risk | None obvious. |