Sun 2009a.

Methods	Allocation: randomised, no further detail. Blindness: unclear. Duration: eight weeks. Design: parallel. Setting: inpatient, China.
Participants	Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more. N = 60. Age: aripiprazole group: 17～50 years. mean = (27. 5 ± 7. 9) years; quetiapine group: 18～51 years, mean = (26. 7 ± 8. 4) years. Gender: aripiprazole group: 23 male, 21 female; quetiapine group: 22 male, 22 female. History: aripiprazole group: mean = (4. 1 ± 2.7) years; quetiapine group: mean = (4. 5± 2. 9) years. Age at onset not reported.
Interventions	1. Aripiprazole: Dose range: 5‐30 mg/day. Mean= (11. 6±4. 6) mg/day. N=30. 2. Quetiapine: Dose range: 50‐600 mg/day. Mean= (407±65) mg/day. N=30.
Outcomes	Global state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐75%, improved: 25%‐50%, no effect: < 25%). Mental state: PANSS total score, PANSS positive subscale score, PANSS negative subscale score, PANSS general psychogenic pathological subscale score. Unable to use ‐ Adverse effects: TESS total score and use of benzodiazepine (no data).
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Randomised, no further details.
Allocation concealment (selection bias)	Unclear risk	Not reported.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Unclear if outcome was assessed blindly.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No incomplete data.
Selective reporting (reporting bias)	High risk	Data on TESS total score, use of benzodiazepine and other medicines were missing.
Other bias	Low risk	None obvious.