Wang 2007.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: eight weeks. Design: parallel. Setting: outpatient, China. |
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Participants | Diagnosis: schizophrenia (CCMD‐3). BPRS of 35 or more.
N = 95.
Age: aripiprazole group: 16~54 years. mean = (24.4 ± 13.2) years; risperidone group: 13~67 years, mean = (25. 4 ± 14. 6) years. Gender: aripiprazole group: 22 male, 24 female; risperidone group: 23 male, 26 female. History: not reported. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Dose range: 5‐30 mg/day. Mean dose: not reported. N = 46. 2. Risperidone: Dose range: 1‐6 mg/day. Mean dose: not reported. N = 49. | |
Outcomes | Global state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐75%, improved: 25%‐50%, no effect: < 25%). Mental state: PANSS total score. Leaving the study early. Adverse effects. Unable to use ‐ Adverse effects: TESS total score, blood routine, use of benzodiazepines and anticholinergic medication (no data). |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | Total proportion of drop‐out was 3.15% and the data of the two groups were balanced (2/46: 1/49). Two because of adverse effect, one due to economic issue. |
Selective reporting (reporting bias) | High risk | Data on TESS total score, blood routine, use of benzodiazepines and anticholinergic medication were missing. |
Other bias | Low risk | None obvious. |