Ye 2005.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: eight weeks. Design: parallel. Setting: inpatient, China. |
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Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS of 60 or more.
N = 68.
Age: aripiprazole group: 18~52 years, mean = (28. 6 ± 16. 8) years; risperidone group: 19~55 years, mean = (31.9 ± 15.7) years. Gender: aripiprazole group: 20 male, 14 female; risperidone group: 24 male, 10 female. History: not reported. Age at onset not reported. |
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Interventions | 1. Aripiprazole: Dose range: 5‐30 mg/day. Mean = (17.5 ± 6.5) mg/day. N = 34. 2. Risperidone: Dose range: 1‐6 mg/day. Mean = (4.1 ±1.8) mg/day. N = 34. | |
Outcomes | Global state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐75%, improved: 25%‐50%, no effect: < 25%). Mental state: PANSS total score, PANSS positive subscale score, PANSS negative subscale score, PANSS general pathological subscale score, agitation labelled as "adverse effect". Adverse effects. Unable to use‐ Adverse effects: TESS score, blood and urine routine, liver function, blood glucose (no data). |
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Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No incomplete data. |
Selective reporting (reporting bias) | High risk | Data on TESS total score and blood and urine routine, liver function, blood glucose were missing. |
Other bias | Low risk | None obvious. |