Zhang 2007a.
Methods | Allocation: randomised, no further details. Blindness: unclear. Duration: eight weeks. Design: parallel. Location: inpatient, China. | |
Participants | Diagnosis: schizophrenia (CCMD‐3). PANSS total score of 60 or more. N = 50. Age: aripiprazole group: mean = (10.07 ± 2.35) years; risperidone group: mean = (9.37 ± 4.08) years. Gender: aripiprazole group: 11 Male, 14 Female; risperidone group: 10 Male, 15 Female . History: aripiprazole group: mean = (1.64 ± 3.74) months; risperidone group: mean = (1.87 ± 2.96) months. Age at onset not reported. | |
Interventions | 1. Aripiprazole: Dose range: 5‐20 mg/day. Mean dose: not reported. N = 25. 2. Risperidone: Dose range: 1‐4 mg/day. Mean dose: not reported. N = 25. | |
Outcomes | Global state: PANSS score decreased rate (recovery: ≥ 75%, markedly improved: 50%‐75%, improved: 25%‐50%, no effect: < 25%). Mental state: PANSS total score, PANSS positive subscale score, PANSS negative subscale score, PANSS general psychogenic pathological subscale score. Adverse effects. Unable to use ‐ Adverse effects: blood and urine routines, EEG, use of anticholinergic drug and benzodiazepines (no data). |
|
Notes | ||
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | Unclear risk | Randomised, no further details. |
Allocation concealment (selection bias) | Unclear risk | Not reported. |
Blinding of participants and personnel (performance bias) All outcomes | Unclear risk | Not reported. |
Blinding of outcome assessment (detection bias) All outcomes | Unclear risk | Unclear if outcome was assessed blindly. |
Incomplete outcome data (attrition bias) All outcomes | Low risk | No incomplete data. |
Selective reporting (reporting bias) | High risk | Data on blood and urine routines, EEG, use of anticholinergic drug and benzodiazepines were missing. |
Other bias | Low risk | None obvious. |