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. 2019 Mar 5;9(3):366. doi: 10.3390/nano9030366

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© 2019 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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(a) The scheme of capturing circulating tumor cells (CTCs) from the blood sample. The system involves: a vacuum pump, Buchner flask, and filter funnel. The surface-enhanced Raman spectroscopy (SERS) platform was placed on the filter funnel and a droplet of blood spiked with CTCs was put on the platform. After turning on the pump, the liquid was sucked through the mat to the flask, whereas the CTCs remained on the surface of the SERS platform. (b) Filtration process of the fluid with the CTCs. The setup consists of a ceramic filter and SERS-active platform placed in the very center. After pipetting a small amount of fluid (top) with CTCs, the vacuum pump is turned on and the blood passes through the mat and the ceramic filter to the Büchner flask, whereas the CTCs stay on the SERS-active platform (steps i–iv).