Boyer 1987.

Methods	Allocation: randomised. Blindness: not stated. Duration: 3 weeks washout plus 6 weeks treatment period. Setting: not stated. Design: parallel.
Participants	Diagnosis: schizophrenia (DSM‐III). N = 62. Age: 21‐53 years old. Sex: 43 men, 19 women. Duration ill: mean˜12.3 years, SD˜4.7 years. Inclusion criteria: duration ill between 1 to 20 years; absence of marked positive symptoms; score >7 on DSAS. Exclusion criteria: not received antipsychotics in previous month.
Interventions	1. Fluphenazine: 2 mg to 12 mg/day. N = 28. 2. Amisulpride: 50 mg to 300 mg/day. N = 34.
Outcomes	Mental state: BPRS.* Leaving the study early. Unable to use ‐ Mental state: DSAS (not a validated scale). Behaviour: NOSIE (no SD reported). Adverse effects: physiological measures, CHESS (no data reported).
Notes	* The published papers clearly report SD as measure of variance but these seem to be SE and we treat them as such.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Quote: "After a 3‐week washout period, participants were randomly assigned" ‐ no further details. (p.296).
Allocation concealment (selection bias)	Unclear risk	Not stated.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Double‐blind.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not stated.
Incomplete outcome data (attrition bias) All outcomes	High risk	Five participants did not complete ratings for various BPRS components.
Selective reporting (reporting bias)	High risk	Did not report complete data for NOSIE and CHESS.
Other bias	Unclear risk	None obvious.