Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2019 Apr 12;10:797. doi: 10.3389/fimmu.2019.00797

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2019 Bucher, Schlundt, Wulsten, Sass, Wendler, Ellinghaus, Thiele, Seemann, Willie, Volk, Duda and Schmidt-Bleek.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Fracture healing outcome of humanized PBMC mice. (A) Representative image of a 21 days old fracture gap. (B) Human immune cells settled to spleen and bone marrow in significant levels after transfer. (C) Healing under the influence of either experienced or more naïve peripheral blood mononuclear cells (hPBMC) showed a beneficial effect of a more naïve immune phenotype. The bone volume in total volume (BV/TV) was significantly increased under the influence of more naïve hPBMC compared to the control without hPBMC and more experienced hPBMC. The bone mineral density (BMD) and trabecular thickness (Tb.Th) stood to benefit from immune cells. The more naïve hPBMC further increased the mineral density within the fracture gap compared to more experienced hPBMC. The number of newly formed trabecular structures (Tb.N) seemed to decrease under the influence of more experienced hPBMC. N = 6 animals in the naïve hPBMC group, N = 8 each in control and experienced hPBMC group, boxplot distribution with median, Mann-Whitney U-test, ^*p < 0.05.