Fig. 2.

OPN deficiency decreases APAP-induced liver injury at the early phase. Fasted WT and Opn^−/− mice were subjected to a single dose of APAP. Serum levels of ALT (a) and AST (b) at the indicated time points after APAP treatment (n = 3–6). c Representative images of HE staining in liver sections of WT and Opn^−/− mice at the indicated time points after APAP challenge (origin magnification ×100). d Quantification of necrotic areas in liver sections by HE staining (n = 3–6). Data are shown as the means ± SEM, *P < 0.05