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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Biomaterials. 2019 Feb 19;202:1–11. doi: 10.1016/j.biomaterials.2019.02.018

Fig. 4.

Fig. 4.

Substrate stiffness alters the expression of drug resistance genes. (a) Gross changes in MDA-MB-453 gene expression when cultured on 5 kPa or 30 kPa PA gels compared to cells grown on glass, in units of log2 (p<1×10−6). Cutoffs were set at ≥2 folds up-regulated (green) or ≤−2 folds down-regulated (red). (b-d) Fold change in the expression of genes associated with resistance (orange) or sensitivity (purple) of cells towards (b) PTX, (c) DOX or (d) MTX/5FU, following culture of MDA-MB-453 on 5 kPa gels versus glass. (e) Fold change in selected oncogene/proto-oncogenes (yellow) and tumor suppressor genes (blue). P value cutoff for panels b–e set at p<0.05. Data is averaged from n = 4 biologic replicates.