Table 3.
c.2194 polymorphism and its correlation with toxicity
| Total n. | % | c.2194G/G no. | % | c.2194 (G/A)+(A/A) no. | % | p | OR | 95% CI | ||
|---|---|---|---|---|---|---|---|---|---|---|
| All toxicities | NO | 192 | 52 | 180 | 56 | 12 | 26 | |||
| YES | 174 | 48 | 140 | 44 | 34 | 74 | 0.0001 | 3.548 | 1.779–7.076 | |
| Haematological | NO | 275 | 75 | 253 | 79 | 22 | 48 | |||
| YES | 91 | 25 | 67 | 21 | 24 | 52 | <0.0001 | 4.090 | 2.161–7.741 | |
| Neutropenia | NO | 276 | 75 | 253 | 79 | 23 | 50 | |||
| YES | 90 | 25 | 67 | 21 | 23 | 50 | <0.0001 | 3.756 | 1.986–7.106 | |
| Intestinal | NO | 299 | 82 | 260 | 81 | 39 | 85 | |||
| YES | 67 | 18 | 60 | 19 | 7 | 15 | 0.5624 | 0.817 | 0.354–1.889 | |
| Others | NO | 335 | 92 | 293 | 92 | 42 | 91 | |||
| YES | 31 | 8 | 27 | 8 | 4 | 9 | 0.9531 | 1.130 | 0.393–3.253 |
Others = skin, cardiac, hepatic, fatigue, renal, mucositis, thromboembolism, ischaemia, pancreatitis