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. 2019 Apr 12;11:79. doi: 10.3389/fnagi.2019.00079

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Copyright © 2019 McKetton, Cohn, Tang-Wai, Sobczyk, Duffin, Holmes, Poublanc, Sam, Crawley, Venkatraghavan, Fisher and Mikulis.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) The 2-branch vascular resistance model used to convert voxel blood oxygen dependent (BOLD) vs. PETCO₂ to voxel resistance vs. PETCO₂. (B) The sigmoidal change of vascular resistance as a function of PETCO₂ showing the various sigmoid parameters. Abbreviations: MAP = mean arterial pressure, Rart = major cerebral arteries resistance, Pbranch = voxel perfusion pressure, Rvox = examined voxel resistance, Rref = reference voxel resistance, Fvox = examined voxel blood flow, Fref = reference voxel blood flow, Ftotal = total blood flow through both branches, Pv = venous pressure.