Table 2.
Lipid molecular species altered in serum of ZIKV versus control patients as revealed by volcano plot analysis.
| Lipid species∗ | FC | log2(FC) | raw.pval | -log10(p) |
|---|---|---|---|---|
| pPE p18:0/20:4 | 2.265 | 1.180 | 0.001 | 3.171 |
| pPE p18:0/22:6 | 2.140 | 1.098 | 0.001 | 3.055 |
| pPE p18:0/18:1 | 2.037 | 1.027 | 0.001 | 3.021 |
| pPE p18:1/20:4 | 2.295 | 1.199 | 0.001 | 2.978 |
| pPE p16:0/22:5 | 2.541 | 1.346 | 0.001 | 2.971 |
| pPE p18:1/18:2 | 2.080 | 1.056 | 0.001 | 2.880 |
| pPE p16:0/20:4 | 2.198 | 1.136 | 0.002 | 2.669 |
| pPE p18:1/22:6 | 2.005 | 1.004 | 0.006 | 2.208 |
| pPE p16:0/22:6 | 2.057 | 1.040 | 0.007 | 2.157 |
| pPE p20:0/20:4 | 1.812 | 0.857 | 0.008 | 2.109 |
| pPE p18:0/18:2 | 1.933 | 0.951 | 0.011 | 1.943 |
| PE 18:0/22:5 | 1.685 | 0.752 | 0.013 | 1.881 |
| PE 18:0/20:4 | 1.753 | 0.810 | 0.016 | 1.805 |
| pPE p16:0/18:2 | 1.882 | 0.912 | 0.016 | 1.800 |
| PE 16:0/22:5 | 1.844 | 0.883 | 0.027 | 1.575 |
| PE 18:1/20:4 | 1.844 | 0.883 | 0.027 | 1.575 |
| PE 18:0/20:3 | 1.625 | 0.700 | 0.036 | 1.441 |
| PE 16:0/20:4 | 1.697 | 0.763 | 0.039 | 1.408 |
∗Annotation of lipids: headgroup abbreviation followed by side-chain characteristics. For x:y number of carbons (x) followed by number of double bonds (y). For plasmalogens px:y indicates the number of carbons and double bonds in the ether-linked vinyl chain, followed by the fatty acid chain characteristics. Identified lipid species were annotated by a shorthand nomenclature corresponding to the level of detail attainable by the analysis (e.g., PE 16:0/20:4). The symbol “/” denotes constituting fatty acids moieties of the lipid species, and not their sn-1 and sn-2 position on the glycerol-backbone.