Figure 5.

Relationship between sugar phosphorylation and PEP-pyruvate conversion in the archaeal species Sul. solfataricus, Tpt. tenax, and Tco. kodakarensis. For simplicity, only the cosubstrates for the energy converting reactions in the EMP and branched ED pathway are shown. Enzymes are depicted in italics. Red, blue, or violet arrows indicate unidirectional glycolytic and gluconeogenic as well as reversible reactions, respectively. Established inhibitors are given in red. For abbreviations see Figure 4; PFK, phosphofructokinase; PPDK, pyruvate:phosphate dikinase; fructose 1,6-P₂, fructose 1,6-bisphosphate; PP_i, pyrophosphate.