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. 2019 Apr 12;13:13. doi: 10.3389/fnint.2019.00013

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Copyright © 2019 Minalyan, Gabrielyan, Pietra, Taché and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effect of orogastric daily administration of HM01 (3 mg/kg) for 10 days on average daily fecal weight (A), fecal water content (B), fecal dry weight (C), fecal pellets (D), and intake of water (E) and food (F) in rats microinjected with 6-OHDA or vehicle unilaterally into the medial forebrain bundle (3–4 weeks before). Data are mean ± SEM calculated per 300 g of body weight (bw). Rats/group are indicated in each bar of graph (A). p < 0.05 as *: vs. vehicle/vehicle, #: vs. 6-OHDA/vehicle and §: vs. vehicle/HM01 by one-way and two-way ANOVA. Correlation of the average 24-h water intake with fecal weight (G) and with fecal water content (H) during 10 days treatment of HM01 (og at 3 mg/kg) analyzed by linear regression.