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. 2019 Apr 12;13:13. doi: 10.3389/fnint.2019.00013

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Copyright © 2019 Minalyan, Gabrielyan, Pietra, Taché and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Body weight and composition of rats microinjected with 6-OHDA or vehicle unilaterally into the medial forebrain bundle after HM01 or vehicle treatments. HM01 (3 mg/kg) or vehicle was administered og daily for 10–12 days starting from 3 to 4 weeks after microinjection of 6-OHDA. (A) Body weight; (B) fat mass; (C) lean mass; (D) total body water. Body fat mass (E) and body weight (F) are correlated with food intake. Data are mean ± SEM. Rats/group are indicated in each bar of graph (A). p < 0.05 as *: vs. vehicle/vehicle, and #: vs. 6-OHDA/vehicle by one-way ANOVA. Two-way ANOVA revealed an interaction between 6-OHDA and HM01 on changes of body weight, lean mass and total body water (p > 0.05), and the HM01 increased body fat mass (p < 0.05).