Table 1.
No desensitization of HM01 effect in 6-OHDA rats during the treatment.
| Day | 0* | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 | 10 | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Fecal weight | 6.9 ± 0.3 | 7.9 ± 0.2 | 8.3 ± 0.1 | 7.9 ± 0.2 | 8.0 ± 0.4 | 8.0 ± 0.3 | 7.4 ± 0.3 | 7.5 ± 0.3 | 7.6 ± 0.3 | 7.4 ± 0.4 | 7.7 ± 0.3 | F = 1.16, p > 0.05 |
| Fecal water | 1.4 ± 0.1 | 1.7 ± 0.1 | 2.0 ± 0.1 | 1.9 ± 0.1 | 2.0 ± 0.2 | 2.1 ± 0.2 | 1.7 ± 0.2 | 1.8 ± 0.2 | 1.9 ± 0.2 | 1.9 ± 0.2 | 2.1 ± 0.1 | F = 1.16, p > 0.05 |
| Water intake | 19.7 ± 0.7 | 24.5 ± 0.7 | 24.0 ± 1.2 | 23.7 ± 0.7 | 24.4 ± 0.5 | 24.0 ± 0.8 | 23.5 ± 0.6 | 22.0 ± 1.0 | 23.4 ± 0.9 | 21.4 ± 0.3 | 23.2 ± 0.9 | F = 1.83, p > 0.05 |
| Food intake | 25.2 ± 2 | 30.6 ± 0.9 | 32.5 ± 1.5 | 32.4 ± 1.2 | 32.9 ± 1.0 | 32.7 ± 1.6 | 30.0 ± 1.3 | 28.4 ± 1.2 | 29.1 ± 0.9 | 27.1 ± 1.1 | 28.4 ± 1.5 | F = 7.45, p <0.05§ |
Data are means/24 h ± SEM, n = 8, analyzed by one-way repeated measures analysis of variance. 0*: measurements in 6-OHDA rats before HM01 treatment, p < 0.05 vs. days with HM01. §: significant as 24-h food intake on D2–D5 compared with Day 7, 9 or 10, but not with Day 1, and not D1 vs. D10.