Table 1.

No desensitization of HM01 effect in 6-OHDA rats during the treatment.

Day	0*	1	2	3	4	5	6	7	8	9	10
Fecal weight	6.9 ± 0.3	7.9 ± 0.2	8.3 ± 0.1	7.9 ± 0.2	8.0 ± 0.4	8.0 ± 0.3	7.4 ± 0.3	7.5 ± 0.3	7.6 ± 0.3	7.4 ± 0.4	7.7 ± 0.3	F = 1.16, p > 0.05
Fecal water	1.4 ± 0.1	1.7 ± 0.1	2.0 ± 0.1	1.9 ± 0.1	2.0 ± 0.2	2.1 ± 0.2	1.7 ± 0.2	1.8 ± 0.2	1.9 ± 0.2	1.9 ± 0.2	2.1 ± 0.1	F = 1.16, p > 0.05
Water intake	19.7 ± 0.7	24.5 ± 0.7	24.0 ± 1.2	23.7 ± 0.7	24.4 ± 0.5	24.0 ± 0.8	23.5 ± 0.6	22.0 ± 1.0	23.4 ± 0.9	21.4 ± 0.3	23.2 ± 0.9	F = 1.83, p > 0.05
Food intake	25.2 ± 2	30.6 ± 0.9	32.5 ± 1.5	32.4 ± 1.2	32.9 ± 1.0	32.7 ± 1.6	30.0 ± 1.3	28.4 ± 1.2	29.1 ± 0.9	27.1 ± 1.1	28.4 ± 1.5	F = 7.45, p <0.05§

Data are means/24 h ± SEM, n = 8, analyzed by one-way repeated measures analysis of variance. 0*: measurements in 6-OHDA rats before HM01 treatment, p < 0.05 vs. days with HM01. ^§: significant as 24-h food intake on D2–D5 compared with Day 7, 9 or 10, but not with Day 1, and not D1 vs. D10.