An integrated prognostic scoring system for metastatic lung adenocarcinomas. (A) Histogram of the prognostic risk score computed using the OncoCast model in 1,054 metastatic lung adenocarcinomas. The risk score is scaled from 0 to 10, with a higher score indicating higher likelihood of shorter survival. Dashed lines indicate the percentile cutoffs used to stratify patients into four risk subgroups (low, intermediate-low, intermediate-high, and high). (B) Boxplots of concordance index for predicting overall survival using clinical demographic factors including age, sex, smoking, and the OncoCast risk score. CN, copy number; mut, mutation.