(A) Experimental timelines showing MDI exposed time points, routes. Expression levels of candidate circulating (B) mmu-miR-183-5p, (C) mmu-miR-206-3p, and (D) mmu-miR-381-3p were compared to control mice without dermal and airway MDI-aerosol exposure control (N=3; bars, s.e.m.). MDI: 4,4’-methylene diphenyl diisocyanate; ACN: acetone. (***P<0.001).