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. Author manuscript; available in PMC: 2019 Dec 13.
Published in final edited form as: Cell. 2018 Dec 13;175(7):1931–1945.e18. doi: 10.1016/j.cell.2018.11.028

Figure 1: Summary of the DENV-human protein-protein interaction network.

Figure 1:

(A) Overall pipeline for the integrated AP-MS and RNAi approach to define DENV-human PPIs. (B) Schematic of RNAi screening approach. (C) RNAi knockdown efficiency for 37 genes measured by RT-qPCR. (D) Summary of RNAi screening of 350 host factors using quadruplicate measurements. (E) ROC analysis of MiST training using RNAi data, and additional filtering by CompPASS. (F) Functional enrichment analysis by bait. Highly similar categories with significant enrichment (false discovery rate (FDR) corrected q value < 0.05) were combined (Table S4), and the most conservative q values of combined terms are plotted. (*) indicates established role in flavivirus biology. (G) Overlap of DENV-human network with Flaviviridae protein interaction datasets. (H) Overlap of DENV-human network with Flaviviridae genetic datasets.