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. 2019 Apr 19;14(4):e0215033. doi: 10.1371/journal.pone.0215033

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© 2019 Reisdorf et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — Hematoxylin and eosin (H&E; A-C) and EPHX2 immunohistochemical (IHC; D-I) staining in human normal, CD and UC biopsy samples. Minimal cytoplasmic EPHX2 IHC staining is present in the colonocytes of the normal colon sample (D & G) with no EPHX2 IHC staining evident in the lamina propria leukocytes. Increased EPHX2 immunoreactivity was observed in the CD and UC samples. Marked cytoplasmic colonocyte and minimal to mild lamina propria leukocyte (arrow) EPHX2 IHC staining is present in the CD sample (E & H); whereas, mild cytoplasmic colonocyte and minimal lamina propria leukocyte (arrow) EPHX2H IHC staining is present in the UC sample (F & I).