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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: J Alzheimers Dis. 2019;67(3):1089–1106. doi: 10.3233/JAD-180923

Fig. 11.

Fig. 11.

Current model for potential interactions among AβPP, cKit, Shp2, and Gab2. Gab2 is a scaffold protein found by GWAS to be associated with AD. Inhibition of cKit and Shp2 increases AβPP phosphorylation on the Y743 residue resulting in a reduction in Aβ production. Kinase and phosphatase inhibitors that increased AβPP phosphorylation and reduced Aβ formation are in pink boxes. Yellow P, pSer; Green P, pTyr; SCF, stem cell factor.