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. Author manuscript; available in PMC: 2019 Jul 1.
Published in final edited form as: J Alzheimers Dis. 2019;67(3):1089–1106. doi: 10.3233/JAD-180923

Fig. 5.

Fig. 5.

Y10 enhances phosphorylation at AβPP Y743. A) Schematic representation of the three isoforms of AβPP and the tyrosine residues in the cytosolic C-terminus. Kunitz protease inhibitor (KPI), transmembrane and Aβ domains are indicated. The C-terminal sequence is shown with the three tyrosine (Y) residues in bold. The numbering corresponding to the three isoforms of AβPP is indicated. B) IP-WB analysis of the effects of Y10 at 1 μM on AβPP phosphorylation of WT AβPP751 or AβPP751 mutants (Y709G, Y738G, and Y743G) on each tyrosine residue in the C-terminal domain on transfected HEK293 cells. C) Statistical analysis of (A). Results normalized to AβPP input. p-Y, phosphorylated Tyr; C, control DMSO treated; Y10, Y10 treated. Results are mean ± standard deviation, n=3. Asterisks (*) indicate statistical significance of p<0.05 by t-test.