Interacting partners of whirlin at various subcellular locations in the inner ear and retina. (A) Whirlin interacts with EPS8, MYO15A, p55, and CASK proteins at the stereociliary tip of inner ear hair cells, where MYO15A and EPS8 also interact with each other. (B) Whirlin interacts with ADGRV1, usherin, and PDZD7 at the stereociliary base in inner ear hair cells, where the four proteins interact among one another and form the ALC. (C) Whirlin interacts with ADGRV1 and usherin at the PMC and with SANS and RPGRorf15 at the connecting cilium in photoreceptors.