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Preparation of Tetrapeptide Fragment 8. Reagents and conditions: (a) NaH, MeI, THF; (b) L-Pro-OMe, HATU, DIPEA, DCM, 62% (2 steps); (c) (1) TFA, DCM; (2) Boc-Gly, HATU, DIPEA, DCM, 80% (2 steps); (d) (1) TFA, DCM; (2) Boc-Val-OH, HOBt, EDCI, DMF, 62% (2 steps).
