Table.

Screening Guidelines for Barrett’s Esophagus

Society or group	Risk categories for Barrett’s esophagus					Recommendations for screening	Recommendations against screening
	Age	Sex	Race	Morphologic features	Clinical history
American Gastroenterological Association (2011)6	≥ 50 years	Male	Caucasian	Elevated BMI; intra-abdominal distribution of body fat	Chronic GERD Hiatus hernia	Patients with multiple risk factors	General population with GERD without risk factors
American College of Physicians (2012)7	> 50 years	Male	NA	Elevated BMI Intra-abdominal distribution of fat	Nocturnal reflux symptoms Hiatus hernia Tobacco use	Men > 50 years with > 5 years of GERD symptoms and additional risk factors (nocturnal reflux symptoms, hiatal hernia, elevated BMI, tobacco use, and intra-abdominal distribution of fat)	Routine screening in women, regardless of GERD symptoms
British Society of Gastroenterology (2014)8	≥ 50 years	Male	Caucasian	Obesity	Chronic GERD	Chronic GERD symptoms and at least 3 risk factors Threshold of multiple risk factors should be lowered in the presence of family history (at least one first-degree relative with BE or EAC).	Unselected population with GERD symptoms without risk factors
American College of Gastroenterology (2016)9	> 50 years	Male	Caucasian	Central obesity (waist circumference > 88 cm, waist to hip ratio > 0.8)	> 5 years of GERD symptoms and/or frequent (weekly or more) symptoms Current or past smoking history Family history (confirmed family history of BE or EAC in a first-degree relative)	Men with > 5 years of GERD symptoms (heartburn or acid regurgitation) and/or frequent (weekly or more) symptoms, and 2 or more risk factors for BE or EAC	General population screening without risk factors Screening in females
Cancer Council Australia (2015)10	Increasing age	Male	NA	Central obesity	Waist-hip ratio Central adiposity Smoking history Family history of EAC and/or BE	Clinical evaluation of future risk of BE should consider age, sex, GERD history, waist-hip ratio, other features of central adiposity, smoking history, and family history of EAC and/or BE.	General population screening, even if conducted coincident with colonoscopy screening, is not cost-effective.
Asia-Pacific Expert Consensus (2016)11	Older age	Male	Caucasian	NA	Long duration of reflux symptoms, Abdominal obesity, smoking	NA	94.7% agreement that there is no value for screening for BE in the Asia-Pacific region due to low prevalence and lack of benefit
Asociacion Mexicana de Gastroenterologia (2016)12	> 50 years	Male	NA	Obese or overweight	GERD symptoms > 5 years Hiatus hernia Smoking	Intentional search for BE is justified in subjects with various risk factors: men > 50 years, a history of GERD symptoms > 5 years, especially if the patient is obese or overweight.	GERD symptoms alone (not sufficient justification for screening)

BMI, body mass index; GERD, Gastroesophageal reflux disease; NA, not applicable; BE, Barrett’s esophagus; EAC, esophageal adenocarcinoma.