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. 2019 Apr 30;25(2):189–204. doi: 10.5056/jnm18172

Figure 2.

Figure 2

Immunohistochemical labeling of receptor tyrosine kinase Kit+ intramuscular interstitial cells of Cajal (ICC-IM) in the monkey and mouse rectoanal regions. (A) ICC-IM are highly branched stellate-shaped cells in the monkey internal anal sphincter (IAS) whereas (B) they are more spindle-shaped in rectum and run parallel to smooth muscle cells (SMCs). (C, D) Intramuscular ICC also run parallel to SMCs in the wildtype mouse IAS and rectum but are spindle-shaped. While ICC-IM in monkey rectum (B) are less branched than in the monkey IAS (A), they are more branched than ICC-IM in the mouse IAS (C) and rectum (D).