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. Author manuscript; available in PMC: 2019 Jun 19.
Published in final edited form as: Oncogene. 2018 Dec 19;38(16):2967–2983. doi: 10.1038/s41388-018-0608-2

Figure 8. Optimized structures for the complexes formed between acetamide w/o protonated and phosphorylated tyrosine.

Figure 8.

(A) non-protonated acetamide and Tyr- Tyr-OPO3H-. (B) Protonated acetamide and Tyr-OPO3H-, where the involved oxygens on Tyr-OPO3H- are both not protonated. (C) Protonated acetamide and phosphorylated tyrosine, where the protonated C=O on acetamide interacts as a proton donor with the protonated P-O on Tyr-OPO3H-. (D) Protonated acetamide and Tyr-OPO3H-, where the protonated C=O on acetamide interacts as an electron lone pair donor with the protonated P-O on Tyr-OPO3H-.