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. Author manuscript; available in PMC: 2019 Dec 4.
Published in final edited form as: Biochemistry. 2018 Nov 15;57(48):6653–6661. doi: 10.1021/acs.biochem.8b00986

Table 2.

Structure of acinetobactin analogs and associated properties.

graphic file with name nihms-997543-t0006.jpg CAS (+/-)1 A. baumannii Growth Promotion (+/-)1 BauB Apparent Kd (nM)2
1, R1 = 2,3-OH; R2 = Im + ++ 300 ± 100
1-Fe, R1 = 2,3-OH; R2 = Im NA +++ 160 ± 80
3, R1 = 2,3-OH; R2 =CH2Im + + 320 ± 130
4, R1 = 2-OH; R2 = Im – – 520 ± 270
5, R1 = 3-OH; R2 = Im – – 250 ± 70
6, R1 = 4-OH; R2 = Im – – 250 ± 70
7, R1 = 2,3-OMe; R2 = Im – – 270 ± 70
8, R1 = H; R2 = Im – – 520 ± 220
9, R1 = 2,3-OH; R2 = Me + + 320 ± 130
1

Results from CAS assay and A. baumannii growth promotion were reported previously.27 For the CAS assay, + indicates a positive result correlating to Fe binding and a – indicates no apparent Fe binding. For the growth promotion of A. baumannii, a +/++/+++ indicates positive promotion of growth with more ‘+’ symbols correlating to more relative growth.

2

Experiments were performed in duplicate as independent trials. Error represents standard deviation from the mean.p

3

NA = not applicable.