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Pharmacokinetic profile of the investigational prodrug PPD. Plasma concentration of PPD (ID = 2 mg/kg, formulated at 500 μM) administered as (A) colloids (0.04% PLAC–PEG) or (B) solubilized monomer (5% UP80). Trend line denotes exponential decay fitting of the lambda elimination phase. (C) Pharmacokinetic parameters of noncompartmental analysis show improvement in colloidal PPD half-life due to decreased clearance, resulting in increased AUC (n = 3–6, mean + SD).
