Skip to main content
. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Biol Psychiatry. 2018 Dec 27;85(9):760–768. doi: 10.1016/j.biopsych.2018.12.013

Figure 2. Loss of Cc2d1a causes male-specific disruption of PDE4D and CREB activity in the hippocampus.

Figure 2.

A. Schematic of CC2D1A as a signaling scaffold for PDE4D and PKA upstream of CREB. B-E. Conditional removal of Cc2d1a in cKO male mice causes increased phosphorylation and activity of PDE4D (B.), leading to reduced levels of cAMP (C.), and decreased phosphorylation of both PKA (D.) and CREB (E.) in hippocampal lysates. F-I. No changes in PDE4D (F.), cAMP (G.), PKA (H.) or CREB (I.) are found in the female hippocampus. Results expressed as mean ± SEM. Data averages and statistical information are reported in the Results. Two-tailed t-test with equal variance * p<0.05, ** p<0.01, *** p<0.001