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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Biol Psychiatry. 2018 Dec 27;85(9):760–768. doi: 10.1016/j.biopsych.2018.12.013

Figure 5. GEBR-7b treatment rescues spatial memory deficit in Cc2d1a cKO males and has no effect on females.

Figure 5.

A. The learning delay in the hidden platform (HP) trial of the MWM found in male Cc2d1a cKO animals is corrected by 3μg/kg GEBR-7b treatment for 14 days before testing. Two way ANOVA effect of treatment in hidden platform test p=0.011. B-C. Significant improvement following GEBR-7b treatment are found in both HP1 and HP2 testing days via one way ANOVA for individual days. *** p<0.001 D. No significant change is found in the Probe test. E-H. GEBR-7b treatment has no effect on female mice.