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. Author manuscript; available in PMC: 2020 May 1.
Published in final edited form as: Birth Defects Res. 2019 Mar 1;111(8):380–388. doi: 10.1002/bdr2.1459

Figure 2:

Figure 2:

Maternal Anti-Ro/SSA and/or anti-La/SSB autoantibodies pass through the placenta . It is hypothesized that they A: bind to L-type Calcium Receptors on fetal cardiomyocytes preventing uptake of calcium possibly leading to cellular apoptosis. Alternatively, B: they may bind to internal target antigens released during physiologic apoptosis which are then opsonized by maternal circulating antibodies. This leads to activation of the TLR 7/8 cascade. Both hypotheses result in inflammation, fibrosis and eventual calcification of the cardiac system resulting in CHB.